Transactions of Nonferrous Metals Society of China The Chinese Journal of Nonferrous Metals

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中国有色金属学报

ZHONGGUO YOUSEJINSHU XUEBAO

第9卷    第3期    总第32期    1999年9月

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文章编号:1004-0609(1999)03-0651-04
羟基磷灰石溶胶及其对瘤细胞增殖的影响
冯凌云  李世普  陈闻杰  闫玉华

(武汉工业大学 生物材料与工程研究中心, 武汉 430070)

摘 要: 用Ca(OH)2饱和溶液在超声波作用下制备出稳定的羟基磷灰石溶胶 (HAP-sol)。X射线衍射,TEM和电子衍射测试表明溶胶中的HAP由针状微晶组成。体外细胞培养实验发现HAP-sol对W-256癌肉瘤细胞和艾氏腹水瘤细胞的增殖均具有较强的抑制作用,HAP-sol与上述瘤细胞接触24 h后其半数有效抑制浓度分别为189 mg /L 和210 mg/L。

 

关键字: 羟基磷灰石溶胶;瘤细胞;半数有效抑制浓度

Preparation of hydroxyapatite-sol and its effect on proliferation of tumour cells
Feng Lingyun, Li Shipu, Chen Wenjie, Yan Yuhua

Biomedical Materials and Engineering Center,  Wuhan University of Technology, Wuhan 430070, P.R.China

Abstract:The Hydroxyapatite-sol(HAP-sol) was synthesized by ultrasonic irradiation. The detections of XRD, TEM and electron diffraction showed that the hydroxyapatite in HAP-sol consisted of needle-like microcrystals. The cell culture experiments in vitro indicated that HAP-sol strongly inhibited the proliferation of W-256 and Aishi abdomen sarcoma cells. Its half effective inhibition concentrations were 189 mg/L and 210 mg/L respectively after HAP-sol was in contact of 24 h with tumour cell.

 

Key words: hydroxyapatite-sol; tumour cell; half effective inhibition concentration

ISSN 1004-0609
CN 43-1238/TG
CODEN: ZYJXFK

ISSN 1003-6326
CN 43-1239/TG
CODEN: TNMCEW

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