(武汉工业大学生物材料与工程研究中心，武汉 430070
湖北医科大学附属二医院，武汉 430071)
摘 要: 用羟基磷灰石(Ca10(PO4)6(OH)2，简称HA)和对照材料钛合金制备了经皮元件试样，并将试样穿皮植入受试动物背部皮内进行实验。通过分期对植入局部皮肤组织形态学观察，就材料对皮肤组织的炎性反应和表皮向下生长情况进行了对照研究。结果表明：钛合金材料周围组织局部慢性炎性细胞浸润，轻度充血和水肿，有严重的表皮向下生长；HA材料周围组织未 明显炎性细胞浸润，各观察期均无显著的表皮向下生长，材料与皮肤组织结合紧密，组织相容性良好。
关键字: 经皮元件 羟基磷灰石(HA) 炎性反应 表皮向下生长 组织相容性
（Biomedical Materials and Engineering Research Centre,
Wuhan University of Technology, Wuhan 430070, P. R. China
The Second Affiliated Hospital,Hubei Medical University, Wuhan 430071, P. R. China）
Abstract:The samples of percutaneous device were made of hydroxyapatite (HA) and comparison material, and were percutaneously implanted in the back skin of the animals for experiments. Through histomorphology observations by stages on part skin tissue, the inflammation and the downgrowth of epidermis caused by the materials were comparatively studied. The results demonstrated that part tissue surrounding Ti alloy have chronic inflammatory cells infiltration, slight hyperemia and oedema. Downgrowth of the epidermis is serious, in the case of HA neither clear inflammatory cells infiltration nor marked downgrowth of the epidermis was observed in every observation stage. The material bind tightly with skin tissue. The histocompatibility of HA for percutaneous device is fine.
Key words: percutaneous device; hydroxyapatite; inflammation; epidermis downgrowth; histocompatibility
