(1. 重庆理工大学 材料科学与工程学院,重庆 400054;
2. 重庆市特种焊接材料与技术高校工程研究中心,重庆 400054)
摘 要: 镁及镁合金由于其良好的生物相容性和可降解性能,在生物医用材料领域具有巨大的应用潜力。然而,过快的降解速率限制了其临床应用。羟基磷灰石(HA)涂层具有良好的骨诱导性和骨传导性,可以有效地延缓镁及镁合金的腐蚀速率。但是,单一的羟基磷灰石涂层不能满足镁基植入物的使用寿命要求,因此需对其进一步的改性。本文从生物相容性、可降解性以及力学性能等方面综述镁合金表面以羟基磷灰石为基础,以高分子材料、无机材料以及离子掺杂而成的可降解镁基HA复合涂层的发展和研究现状。
关键字: 镁合金;羟基磷灰石;复合涂层;生物材料
(1. School of Materials Science & Engineering, Chongqing University of Technology, Chongqing 400054, China;
2. Chongqing Municipal Engineering Research Center of Institutions of Higher Education for Special Welding Materials and Technology, Chongqing 400054, China)
Abstract:Magnesium and magnesium alloys have great potential as biomedical materials due to their good biocompatibility and biodegradability. However, the rapid degradation rate limits their clinical application. Hydroxyapatite (HA) coating has good osteoinductivity and osteoconductivity, which can delay the corrosion of magnesium alloy to some extent. But a single hydroxyapatite coating cannot meet the requirements for the clinical service life of magnesium implants, so the HA coating needs to be further modification. In this paper, the research and development about biocompatibility, biodegradability and mechanical properties of HA composite coating modified by polymer, ceramic and doped-ions on magnesium and its alloys were reviewed.
Key words: magnesium alloy; hydroxyapatite; composite coating; biomaterials