(1. 中南大学 材料科学与工程学院，有色金属材料科学与工程教育部重点实验室，长沙 410083； 2. 吉林大学 第二医院骨科，长春 130041)
摘 要: 以3D打印技术制备的多孔Ti6Al4V钛合金支架为研究对象，研究其显微结构特征与力学性能的关系，利用骨髓间充质干细胞研究多孔钛合金支架的生物相容性，以及在家兔全层骨缺损模型中研究支架周围骨质的生长情况。结果表明：3D打印的多孔Ti6Al4V钛合金支架的力学性能受其多孔特性的影响，具有较适合人体需求的初始强度；同时材料具有良好的细胞生物相容性；且多孔支架中的立体网格结构为细胞提供了生长空间，增加了骨髓间充质干细胞的增殖能力，促进了钛合金支架微孔中骨组织长入的速度。
关键字: Ti6Al4V多孔支架；3D打印；力学性能；骨髓间充质干细胞；骨长入；生物相容性
（1. School of Materials Science and Engineering, Key Laboratory of Nonferrous Metal Materials Science and Engineering, Ministry of Education, Central South University, Changsha 410083, China; 2. Department of Orthopedics, The Second Hospital, Jilin University, Changchun 130041, China）
Abstract:Taking titanium alloy Ti6Al4V porous scaffolds by 3D printing as research object, the relationship between the microstructure characteristics and the mechanical properties was preliminarily investigated. Moreover, the bone marrow mesenchymal stem cells were used to investigate the biological compatibility, and the in vivo bone ingrowth ability of the Ti6Al4V porous scaffolds in a rabbit full-thickness bone defect model was detected. The results show that the mechanical properties of Ti6Al4V porous scaffolds prepared by 3D printing are affected by the porous microstructures with the incipient intensity that is suitable for human body. The Ti6Al4V porous scaffolds also have good biocompatibility and absorbability. The detailed grid structure in Ti6Al4V porous scaffolds provides a unique space for cells to grow, which can increase the proliferative ability of the bone marrow mesenchymal stem cells, and promote the ingrowth speed of the surrounding bone tissue in prosthetic microporous.
Key words: Ti6Al4V porous scaffold; 3D printing; mechanical property; bone marrow mesenchymal stem cell; bone ingrowth; biocompatibility
