中国有色金属学报(英文版)
Transactions of Nonferrous Metals Society of China
| Vol. 23 No. 8 August 2013 |
（1. Center for Biomedical Materials and Tissue Engineering, Academy for Advanced Interdisciplinary Studies,
Peking University, Beijing 100871, China;
2. School of Information Engineering, Wenzhou Medical College, Wenzhou 325035, China;
3. Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China）
Abstract:Extensive in vitro corrosion test systems have been carried out to simulate the in vivo corrosion behavior of biodegradable metallic materials. Various methods have their own unique benefits and limitations. The corrosion mechanism of biodegradable alloys and in vitro corrosion test systems on biodegradable metallic materials are reviewed, to build a reasonable simulated in vitro test system for mimicking the in vivo animal test from the aspects of electrolyte solution selection, surface roughness influence, test methods and evaluation methodology of corrosion rate. Buffered simulated body fluid containing similar components to human blood plasma should be applied as electrolyte solution, such as simulated body fluid (SBF) and culture medium with serum. Surface roughness of samples and ratio of solution volume to sample surface area should be adopted based on the real implant situation, and the dynamic corrosion is preferred. As to the evaluation methodology of corrosion rate, different methods may complement one another.
Key words: biodegradable metallic material; in vitro corrosion test; Mg; Fe
