(1. 武汉理工大学 生物材料与工程研究中心,
武汉 430070；
2. 武汉大学 中南医院, 武汉 430072)
摘 要: 磷酸钙（α-TCP/TTCP）复合骨水泥具有良好的水硬性能， 与固化液按固液比为1.50g/mL拌和后， 凝固时间可调， 抗压强度达45.36MPa， 其水化产物为羟基磷灰石（HAP）。 通过体外模拟溶解实验表明, α-TCP/TTCP骨水泥具有一定的溶解性能。通过体外实验、 动物实验， 结合SEM和EPMA观察表明α-TCP/TTCP骨水泥不会产生全身或局部毒性反应，对肌肉无刺激， 不致溶血、 凝血， 不引起炎症和排斥反应等， 有利于骨组织长入并与骨组织紧密接触。 α-TCP/TTCP骨水泥在动物体内可继续水化硬化，且随着植入时间的延长， 材料与宿主骨完全融合在一起。 α-TCP/TTCP骨水泥具有优良的生物相容性和生物活性， 具有一定的降解性能和较好的成骨作用，适合于作为骨缺损的填充材料。
关键字: 磷酸钙骨水泥； 生物相容性； 生物活性
bone cement
（1. Biomedical Materials and Engineering Center, Wuhan University of Technology,Wuhan 430070, China;
2. Zhongnan Hospital, Wuhan University,Wuhan 430072, China）
Abstract:α-tricalcium phosphate(α-TCP)/tetracalcium phosphate(TTCP) composite bone cement (CPC) has good hydration characteristic. CPC powder mixture is mixed with water at a powder/liquid (P/L) ratio of 1.50g/mL. The setting time can be adjusted, the maximal compressive strength is 45.36MPa, and the hydration product is hydroxyapatite (HAP). In vitro biological simulated experiments indicate that α-TCP/TTCP bone cement has certain dissolubility. The hardened product is mainly HAP after soaking in simulated body fluid (SBF) for 10 weeks. The results of in vitro test and animal experiments and SEM analyses show that no local or general toxicity response, no muscle stimulation, no haemolysis, no cruor and no inflammatory reaction, no exclusion response are caused by α-TCP/TTCP cement, which contributes to bone tissue spreading and impinging. α-TCP/TTCP cement hydrates and hardens continually in vivo. The materials fuse with host bone together with implanting time prolonging. α-TCP/TTCP composite bone cement has good biocompatibility and bioactivity, certain biodegradation and good osteogenesis as well. It is qualified as an artificial bone material.
Key words: calcium phosphate bone cement; biocompatibility; bioactivity
