(1.武汉理工大学 生物材料与工程研究中心，武汉 430070;
2.武汉大学 中南医院，武汉 430072)
摘 要: α-TCP/TTCP骨水泥具有良好的水化硬化特性，符合临床需要的凝结时间和抗压强度，其水化产物主要为羟基磷灰石(HAP)。以α-TCP/TTCP骨水泥作为牙根管充填材料，通过体外实验、动物实验，结合组织形态学及扫描电镜观察，检测α-TCP/TTCP牙根管充填材料的组织相容性，并动态观察根尖闭合情况及根尖周组织修复过程。结果表明，材料具有优良的生物相容性，在牙根管内可继续水化硬化，而且能引导根尖钙化组织沉积，封闭根尖孔，形成骨性结合，并促进根尖周组织愈合。
关键字: α-TCP/TTCP；牙根管充填；组织相容性；根尖孔闭合
filling material
（1.Biomedical Materials and Engineering Center，
Wuhan University of Technology，Wuhan 430070，China;
2.Zhongnan Hospital，Wuhan University，
Wuhan 430072，China）
Abstract:A root canal filling material was obtained by mixing α-tricalcium phosphate，tetracalcium phosphate and additives with an aqueous solution containing three carbonyl groups. Powder and liquid were mixed at ratio of 1.25g/mL. This material has good hydration characteristic，appropriate setting time and compressive strength，which accords with the desire of clinic. The biocompatibility of this material was investigated primarily by in vitro test and animal experiments. The α-TCP/TTCP cement was used to fill adult dogs' root canal，the effects of the material on the apical closure，restoration of periapical tissues and adaptability to the dentinal surface were observed by histomorphology and SEM. The results show that α-TCP/TTCP composite cement has excellent biocompatibility with soft and hard tissues，it hydrates and hardens continually in root canal.Its osteoconductivity can promote the formation of calcific barriers and healing of periapicaltissue. The apex can be closed completely.
Key words: α-TCP/T, TCP cement；root canal filling；histocompatibility；apical closure
