(武汉理工大学生物材料与工程研究中心, 武汉 430070)
摘 要: 探讨细胞对可降解多孔磷酸三钙陶瓷（β-TCP）降解的影响及材料骨内植入后在体内超微结构的变化，研究了磷酸三钙陶瓷的生物降解、 新骨生成过程及结构的变化， 为可降解钙磷材料的生物降解和骨生成机制提供依据。 研究结果表明， 材料在体内超微结构的变化是影响材料降解的重要因素之一；钙磷材料通过溶解沉积参与新骨形成， 以OCP， DOHA和HAP的形式存在于骨胶原纤维中，与其他有机质一起构成新骨。
关键字: 磷酸三钙陶瓷; 生物降解; 超微结构; 参与; 新骨形成
（Biomedical Materials and Engineering Center,
Wuhan University of Technology,
Wuhan 430070, China）
Abstract:The effect of cells on the biodegradation of porous tricalcium phosphate (β-TCP) and the ultrastructure transformation of the materials after implantation were studied. The process of biodegradation, new-bone formation and structural change of calcium phosphate ceramics were also investigated. The results provide the direct evidence of the mechanism of biodegradation and osteogenesis for biodegradable calcium-phosphor (Ca-P) ceramics, and show that the ultrastructural transformation of Ca-P in vivo is one of the important factors of biodegradation. No-life Ca-P materials participate in new-bon formation by force of dissolution and deposition. It constitutes bone tissue with other organics together in the form of OCP, DOHA and HAP, which consist in osteocollagenous fibers.
Key words: calcium phosphate ceramics; biodegradation; ultrastructure; participation; bone formation
