Abstract:A composite material was fabricated by applying a biodegradable drug delivery coating, consisting of poly (3-hydroxyburyrate-co-3-hydroxyvalerate) (PHBV) and icariin, to an anodic oxidized titanium plate. The coating was prepared by evaporating chloroform solution containing PHBV and icariin on the titanium plate under vacuum condition. Icariin/PHBV coated titanium plates significantly enhance the proliferation of MG−63 cells compared with the PHBV coated and anodic oxidized ones. Increased icariin contained in the coating displays an elevated influence on cell proliferation. The results show that icariin gradually releases from the coating to cells mainly through the phospholipid-based cellular membrane instead of the culture medium. The overall results suggest that the novel icariin/PHBV coating can be used to enhance the bioactivity of titanium based orthopedic implants.

Key words: poly(3-hydroxyburyrate-co-3-hydroxyvalerate)(PHBV); icariin; drug delivery coating; titanium