中国有色金属学报(英文版)
Transactions of Nonferrous Metals Society of China
| Vol. 21 No. 5 May 2011 |
cetyltrimethyl ammonium bromide-coated single-walled carbon nanotubes
（1. State Key Laboratory for Powder Metallurgy, Central South University, Changsha 410083, China;
2. The Third Xiangya Hospital, Central South University, Changsha 410013, China;
3. Xiangya Medical School, Central South University, Changsha 410013, China）
Abstract:Functionalized carbon nanotubes (CNTs) were made for the delivery of genes and drugs and CNT-based biosensors. The basis of CNTs is for binding with biomolecules in biomedical applications. The binding tendency with small interfering RNA oligonucleotides and cytotoxicity of cetyltrimethyl ammonium bromide (CTAB)-coated single-walled carbon nanotubes (SWNTs) were studied. The field emission scanning electron microscopy and transmission electron microscopy results show that a SWNT suspension in CTAB solution was well-dispersed and stable. CTAB is the cross-linker between SWNTs and oligonucleotides. The CTAB-coated SWNTs have less cytotoxicity to human umbilical vein endothelial cells than single SWNTs and the cytotoxicity of CTAB-coated SWNTs depended on the concentration of CTAB-coated SWNTs.
Key words: single-walled carbon nanotubes; cetyltrimethyl ammonium bromide; oligonucleotides; cytotoxicity
