中国有色金属学报(英文版)
Transactions of Nonferrous Metals Society of China
| Vol. 17 No. 4 August 2007 |
（1. Department of Stomatology, Xiangya Second Hospital, Central South University,
Changsha 410011, China;
2. State Key Laboratory of Powder Metallurgy, Central South University,
Changsha 410083, China）
Abstract:The bioactivity of mica/apatite glass ceramic composites, including the in vitro behavior in simulated body fluid and the histological appearance of the interface between the mica/apatite glass ceramics and the rabbit mandible defect in vivo under a dynamic condition. The results show that biological apatite layer forms on the surface of the mica/apatite glass ceramics after 1 d of immersion in the simulated body fluid, and becomes dense after 14 d. In vivo tests indicate that bone formation occurs after implantation for 14 d, and strong bonding of bone to the implant occurs after 42 d. No aseptic loosening occurs during 42 d of implantation. The finding shows that mica/apatite glass ceramics have good bioactivity and osteoconductivity for constructing bone graft, and can be promising for biomedical application.
Key words: mica/apatite glass ceramics; bioactivity; osteoconductivity
